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How long is the longest I can slow cook pork shoulder?

Everyone seems to say "low and slow" for pork shoulder. 225f or 250f for 8 or more hours. What is the longest / lowest you can do? (without big risk of illnesses) eg, what would happen if you did ...
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Will a pork shoulder be dry after 16 hours at 110C

I'm intending to do the following recipe with an 8lb (3.6kg) bone in shoulder (Essentially 30mins @230C/450F, 16hours @ 110C/230F, 45mins@230C/450F). I'm concerned that such a long cooking time will ...