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How long is the longest I can slow cook pork shoulder?

Everyone seems to say "low and slow" for pork shoulder. 225f or 250f for 8 or more hours. What is the longest / lowest you can do? (without big risk of illnesses) eg, what would happen if you did ...
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Will a pork shoulder be dry after 16 hours at 110C

I'm intending to do the following recipe with an 8lb (3.6kg) bone in shoulder http://www.telegraph.co.uk/foodanddrink/3312736/The-River-Cottage-Meat-Book-part-one-roasting.html (Essentially 30mins ...